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The Stem Cell Source
 News & Views from Cord Blood Registry

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Welcome to The Stem Cell Source:
unique perspectives, commentary and information about a unique source of stem cells. Newborn stem cells from umbilical cord blood are saving lives and changing medicine. As the global leader in the collection and preservation of newborn stem cells, Cord Blood Registry is playing a crucial role in advancing medical research using a child's own cord blood to treat conditions that have no cure today. Join our discussion, spread the word, and learn more at our Web site, www.CordBlood.com.



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November 2009 - Posts

  • 300,000 Reasons to Celebrate the Future of Regenerative Medicine

    Posted: Nov 19, 2009

    CBR recently processed and stored the newborn stem cells from the cord blood of its 300,000th client.  This is a milestone that’s important not just because of its sheer size, but, more importantly, because of what it means for CBR’s leadership role in advancing regenerative medicine.

    A population of 300,000 people is equivalent to a mid-sized U.S. city like New Orleans, Pittsburgh or Tampa.   What happens to the children in cities of this size can also happen to the children whose parents made the decision to entrust the preservation of their child’s newborn stem cells with CBR.

    Based on U.S. government data on the incidence of disease, this means that of the children who have newborn stem cells safely stored at CBR, by the age of six:

    • 1,832 may suffer a traumatic brain injury;
    • 925 may suffer from cerebral palsy;
    • 718 may have suffered acquired hearing loss; and
    • 189 may suffer a stroke – either before birth or after.

    These are all neurological conditions that have no cure today.  However, a growing body of research suggests that the newborn stem cells from a child’s own cord blood may play a role in changing the course of these conditions by helping the body to regenerate damaged tissue and restore lost function.

    To help advance this research, CBR’s Center for Regenerative Medicine is playing the critical role of matching the researchers who are focused on evaluating the use of cord blood in the treatment of these conditions . . . with the children who have these conditions . . . AND who have access to their own newborn stem cells.

    As CBR assists more researchers in initiating human clinical trials, individuals who have access to their own newborn stem cells may be among the first to benefit from these emerging new therapies. 

    However, in order for researchers to be able to know what’s possible with newborn stem cells, they must be saved.  We salute the parents and families of the 300,000+ children whose cells are stored with us for their foresight and confidence in the potential of regenerative medicine.  We, too, look to the future with great optimism and are committed to leading the advancement of regenerative stem cell medicine.

  • Fox News’ Dr. Manny Files Follow-Up Story on Girl Treated With Her Own Newborn Stem Cells

    Posted: Nov 10, 2009

    Some of the most enthusiastic proponents of cord blood banking are families who have firsthand knowledge of its benefits, and the Levine family is no exception. In a one-year follow up story, Dr. Manny Alvarez of Fox News follows the progress of Chloe Levine, a girl with cerebral palsy who was treated with her own newborn stem cells.

    When Chloe was one year old, her parents, Jenny and Ryan, received news that she had suffered from an in-utero stroke before birth, resulting in a diagnosis of right-sided Hemiplegic Cerebral Palsy. Fortunately the Levines had banked Chloe’s cord blood with CBR, which allowed her to undergo an infusion of her own stem cells as part of a study at Duke University. 

    Prior to her treatment, Chloe held her hand in a tight fist, was not holding a bottle, couldn’t push herself up, and was not able to crawl like other babies her age, instead shuffling across the room.  Within four days of Chloe’s infusion, the Levines began to see dramatic changes in their little girl. Chloe, who was nearly paralyzed on her right side, began to lose the rigidity and stiffness in her body, could lift both arms over her head, and began running and jumping.  Today, Fox News reports that Chloe’s progress is still evident: "Her life is completely normal, she doesn’t drag her right foot, she can use her right hand," Jenny Levine said. "She rides a bike, a scooter…we’re taking her skiing this year. She’s fabulous."

    Dr. Joanne Kurtzberg, professor of pediatrics and pathology at Duke University who is conducting the cerebral palsy study, said she “does not know how long the effects of cord blood will last on kids like Chloe, but if there is a good chance it will be ‘durable and last indefinitely’."

    Chloe’s stem cell treatment represents a growing area of interest where researchers today are investigating the use of one’s own cord blood to treat ailments such as brain injury, neurological disorders, and type I diabetes.  Considering the emerging research in the field, the value of cord blood stem cells is not always realized.  Dr. Charles Cox, an expert in pediatric brain injury at the University of Texas Medical School at Houston points out that if parents choose not to save their child’s cord blood, it is discarded as medical waste. 

    "Really, the issue of cord blood banking today comes down to trying to understand what the future holds in terms of regenerative medicine as a field," Cox said. "So, the long-term look is, and even the intermediate-term look is that it’s not science-fiction. I see it expanding and accelerating over the next two to five years."

    View the Fox News Health video story about Chloe’s post reinfusion here

    Read about Chloe’s story online at FoxNews.com

  • Data Presented on Treating Brain Injury in Children with Their Own Cells

    Posted: Nov 05, 2009

    Traumatic brain injury (TBI) is damage to the brain caused by a blow to the head. The resulting injury may be minor and have no lasting effect, or major and result in significant disability or death.  The mortality rate for children following severe TBI ranges from 14-24 percent. While medical and surgical advances have improved the odds of surviving a TBI there is currently no therapy to reverse the injury.

    New research presented earlier this week at the Congress of Neurological Surgeons 2009 Annual Meeting demonstrated improvements in children with TBI who received infusions of their bone marrow stem cells.  The study which is being led by Dr. Charles Cox of the University of Texas, Houston, is an early clinical trial to determine the safety of harvesting and transplanting children’s own bone marrow cells soon after they have suffered a TBI.  The study is also trying to determine if outcomes are improved following the cell transplant.

    The interim results of the study presented by Dr. Cox concluded that no deaths or significant adverse events were associated with the harvest or transplant of bone marrow cells in study participants.  Neurological and functional improvements were also demonstrated over the course of the study.

    This is exciting news for the field of regenerative medicine and has direct relevance for individuals with access to their own cord blood stem cells.  A growing body of evidence suggests that cord blood stem cells can potentially play a role in repairing central nervous system injuries. In comparison to bone marrow, cord blood stem cells are easier to collect and because they are young and undifferentiated cells, have a great ability to multiply.  Autologous stem cells have a long and established clinical record of safe and effective use in humans and researchers plan to conduct studies using cord blood for TBI and other nervous system regenerative applications. 
    You can read more about the causes and prognosis associated with TBI in our October 21st post to The Stem Cell Source, or on the Centers for Disease Control and Prevention Website.